Programme

See below for List of Talks

Invited Lectures:

Jack Szostak: The emergence of RNA from heterogeneous prebiotic chemistry
Carol Greider: Nanopore sequencing reveals chromosome-specific telomere lengths
John Macintosh: Biocatalytic synthesis of nucleoside and nucleotide therapeutics
Peter Neubauer: Enzymatic routes for the cascade synthesis of natural and modified nucleosides
Yitzhak Tor: Expanding the landscape of bioactive isomorphic fluorescent nucleosides
Chris Meier: Membrane permeable Nucleotides for application in Medicinal Chemistry and Chemical Biology
Kathie Seley-Radtke: Fleximers – a strategic approach to broad-spectrum antiviral therapeutics
Ramon Eritja: Nanostructures for delivery of therapeutic oligonucleotides
Anastasia Khvorova, RNA Institute
Satoshi Obika: Recent Progress in the Development of Bridged Nucleic Acids  –Design, Synthesis and Properties of GuNA and BANA
Phil Baran: Reinventing Oligonucleotide Synthesis
Eric Swayze: Use of the mesylphosphoramidate (MsPA) linkage to control of phosphorothioate (PS) content and improve the profile of antisense oligonucleotides
Ivan Zlatev: Spatial architectures for therapeutic small interfering RNAs
Nanna Albaek: Exploring various aspects for developing nucleic acid based medicines for CNS disorders
David Smith: Oligonucleotide based approaches to the treatment of chronic hepatitis B
Leemor Joshua-Tor: A shape-shifting nuclease unravels structured RNA
Sergei Mirkin: Mechanisms of DNA Repeat Expansions: From Yeast to Human Cells
Matthew Wood: Challenge and opportunities in targeted delivery and distribution
Aurelie Goyenvalle: Tricyclo-DNA: promising antisense oligonucleotides for the treatment of neuromuscular diseases
Martin Egli: Crystallographic studies and modeling of RNA structure and siRNA-protein interactions
Katja Petzold: RNA structural changes regulate function by NMR
Ugur Sahin, BioNTech SE

Selected Oral Presentations:

Byron Purse: Fluorescent nucleoside analogues for single-molecule biophysics and for metabolic labeling of RNA
Samantha Kennelly: Development of 3ʹ-Deoxy-3ʹ,4ʹ-didehydro-nucleoside Phosphoramidite Prodrugs as Novel Antiviral Agents
Sunit Kumar Jana: Nucleoside analogues with a seven-membered sugar ring: synthesis and application in CRISPR-Cas gene editing systems
Anders Dahlén: Hit finding and optimization of antisense oligonucleotide therapeutics – How can me make this process more precise and efficient?
Pasi Virta: Decorated molecular spherical nucleic acids for the targeted delivery of oligonucleotides
Kira Astakhova, Technical University of Denmark:
Enhanced specificity and uptake of lipid nanoparticles using novel RNA aptamers and peptides
Thomas Edwardson: Engineering Nonviral Protein Cages for Oligonucleotide Delivery
Francoise Debart: Potent Inhibition of SARS-CoV-2 cap N7- and 2′-O-methyltransferases (nsp14 & nsp16) by sulfonamide-based nucleoside analogues or 5′-cap modified RNAs
Andrei Guzaev: A Novel Type of Universal Solid Supports for Oligonucleotide Synthesis
Luis Miguel Menéndez Méndez: First time use of core-shell type PS-PEG resin for oligonucleotide synthesis
Lucas Bethge: Metabolic stabilization of GalNAc-conjugated siRNA: application of phosphorodithioates allow for a stereo defined mRNAi trigger
Pachamuthu Kandasamy: Synthesis and application of stereopure guanidine-containing backbone to multiple oligonucleotide modalities in preclinical studies
Tom Brown: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
Eriks Rozners: Sequence selective recognition of double-stranded RNA by cationic nucleobase and backbone-modified peptide nucleic acids
Sergei Gryaznov: Telomerase-Driven Telomeric DNA Modification in Cancer Cells Leads to Efficient Induction of cGAS-mediated Innate and Adoptive Immune Responses
Joel Nordin: A Phase I/II study of NS-089/NCNP-02, Exon 44 skipping drug, in patients with Duchenne muscular dystrophy
Philippe Barthelemy: Hydrogel based lipid-oligonucleotides: a new route to self-delivery of therapeutic sequences
Martin Egli: Crystallographic studies and modeling of RNA structure and siRNA-protein interactions
Annemieke Madder: Photo-induced Precision Ligations with Nucleic Acids Through Tailored Singlet Oxygen Generation
John Chaput: Evolution of Functionally Enhanced TNA Aptamers
Jeremy Lackey: DNA Data Storage: Writing the Future, Saving the Past